Date/Time
Date(s) - 14/12/2023
5:30 pm - 7:00 pm
Location
BT2 Détente / Kitchenette 1st Floor room 101
Categories
Do you like scientific discussion? And how about Pizza?
If we gained your attention with ‘scientific’, or at least with ‘Pizza’, then you are already looking forward to the right event!
Pizza Club is a regularly held Journal Club event co-organized by The Representatives of the Doctoral Programme in Systems and Molecular Biomedicine, part of the Doctoral School in Science and Engineering (DSSE); and the Uni.lu student association ISCB RSG Luxembourg.
In short, Students (PhD candidates) present a scientific paper (+- 20 mins) they find interesting or that inspired the development of their individual PhD project (doesn’t need to be authored by the speaker).
There will be a open discussion round after each scientific presentation (2-3 students per event), followed by informal and fun chatting with some pizzas around!
Moreover, each presentation of peer-reviewed papers will be rewarded by 0.5 ECTS!
Speakers :
Carla DUVAL (https://www.linkedin.com/in/carla-duval-33a94b252/)
Introduction: Carla is a first-year PhD student in Pr. Daniel Abankwa’s Cancer Cell Biology and Drug Discovery group. She is working on developing a protein degrader to target and degrade Galectin-3 in order to try to disrupt K-Ras downstream signaling leading to uncontrolled proliferation in cancer.
Article: ‘Identification of KLHDC2 as an efficient proximity induced degrader of K-RAS, STK33, b-catenin, and FoxP3’ (https://doi.org/10.1016/j.chembiol.2023.07.006)
Article description: In this article, the authors present a screening experiment to find new E3 ligases for proximity-induced degradation of protein targets and test a new PROTAC (proteolysis targeting chimeras) design for targeted protein degradation.
Hugues ESCOFFIER (https://www.linkedin.com/in/hugues-escoffier/)
Introduction: 1st year PhD student in System Biology Group supervised by Pr. Thomas Sauter. I’m particularly interested to understand the complex interplay of cancer associated fibroblasts in context of head and neck squamous cell carcinoma (HNSCC) using computational approaches (e.g. pathway enrichment methods and genome scale metabolic network modelling).
Article: Single-cell transcriptomic analysis of primary and metastatic tumor ecosystems in head and neck cancer (https://doi.org/10.1016/j.cell.2017.10.044)
Article description: The article presents a single cell analysis containing 6,000 individual cells from 18 patients with head and neck squamous cell carcinoma (HNSCC). The expression programs of healthy and malignant cells are examined to identify and improve the subtype classification of HNSCCs.
If we attracted your interest by now, feel free to join the monthly Pizza Club, either as part of Audience or as a registered Speaker. For the latter, please kindly use this form to sign up as an upcoming Speaker, by choosing your category of paper and desired month to present. Looking forward to seeing you at the next Pizza Club!
