Date/Time
Date(s) - 30/01/2025
5:30 pm - 7:00 pm
Location
BT2 Détente / Kitchenette 1st Floor room 101
Categories
Do you like scientific discussion? And how about Pizza?
If we gained your attention with ‘scientific’, or at least with ‘Pizza’, then you are already looking forward to the right event!
Pizza Club is a regularly held Journal Club event co-organized by The Representatives of the Doctoral Programme in Systems and Molecular Biomedicine, part of the Doctoral School in Science and Engineering (DSSE); and the Uni.lu student association ISCB RSG Luxembourg.
In short, Students (PhD candidates) present a scientific paper (+- 20 mins) they find interesting or that inspired the development of their individual PhD project (doesn’t need to be authored by the speaker).
There will be a open discussion round after each scientific presentation (2-3 students per event), followed by informal and fun chatting with some pizzas around!
Moreover, each presentation of peer-reviewed papers will be rewarded by 0.5 ECTS!
If we attracted your interest by now, feel free to join the monthly Pizza Club, either as part of Audience or as a registered Speaker. For the latter, please kindly use this form to sign up as an upcoming Speaker, by choosing your category of paper and desired month to present. Looking forward to seeing you at the next Pizza Club!
Please see below the speaker information for this meeting:
PERLA SAOUD (https://lu.linkedin.com/in/perla-saoud-76796869)
- Title : Aspartate signalling drives lung metastasis via alternative translation (https://www.nature.com/articles/s41586-024-08335-7#:~:text=Here%2C%20we%20identify%20an%20additional,translational%20regulation%20of%20collagen%20synthesis).
- Summary: This study explores the role of aspartate in promoting lung metastasis in breast cancer. The study found that high concentrations of aspartate in the lung interstitial fluid of both breast cancer patients and mouse models activate the ionotropic N-methyl-D-aspartate receptor (NMDAR) in disseminated cancer cells. This activation leads to CREB-dependent expression of deoxyhypusine hydroxylase (DOHH), which is crucial for the hypusination of the translation initiation factor eIF5A. The hypusinated eIF5A then initiates a translational program that enhances the aggressiveness of lung metastases, with TGFβ signaling playing a central role in promoting collagen synthesis in the metastatic cancer cells. This mechanism was confirmed by detecting key proteins involved in this pathway in lung metastases from breast cancer patients.
- Bio: Third year PhD student in the Molecular disease and mechanism group at the university of Luxembourg. My work mostly focuses on studying the epigenetic landscape modifications in colorectal cancer upon exposure to gut microbiota derived metabolites.
FRANCESCA BOSHI (https://lu.linkedin.com/in/francesca-boschi-650352231?trk=public_post-text)
- Title: Improving Cuff-Less Continuous Blood Pressure Estimation with Linear Regression Analysis (https://www.mdpi.com/2079-9292/11/9/1442)
- Abstract: This paper is about developing an algorithm for estimating blood pressure in a noninvasive way using ECG and PPG and tuning results with regression techniques.
- Brief bio: I am a first year PhD in dMed group (J. Kluchen), I am a biomedical engineer as background with a specialization in EHealth. I am working analyzing gait data in Parkinson’s disease patient
