Date/Time
Date(s) - 28/03/2024
5:30 pm - 7:00 pm
Location
BT2 Détente / Kitchenette 1st Floor room 101
Categories
Do you like scientific discussion? And how about Pizza?
If we gained your attention with ‘scientific’, or at least with ‘Pizza’, then you are already looking forward to the right event!
Pizza Club is a regularly held Journal Club event co-organized by The Representatives of the Doctoral Programme in Systems and Molecular Biomedicine, part of the Doctoral School in Science and Engineering (DSSE); and the Uni.lu student association ISCB RSG Luxembourg.
In short, Students (PhD candidates) present a scientific paper (+- 20 mins) they find interesting or that inspired the development of their individual PhD project (doesn’t need to be authored by the speaker).
There will be a open discussion round after each scientific presentation (2-3 students per event), followed by informal and fun chatting with some pizzas around!
Moreover, each presentation of peer-reviewed papers will be rewarded by 0.5 ECTS!
- Sophia Croce (https://www.uni.lu/fstm-en/people/sophia-croce)
Presenter introduction: Sophia is a first year PhD student in the Epigenetics Team of the System Biology group at the DLSM, working under the supervision of Dr. Lasse Sinkkonen. They are studying the microbiome-driven epigenetic changes in a colon cancer setting.
Article: “Modulation of the Host Cell Transcriptome and Epigenome by Fusobacterium nucleatum” Despins, Cody A et al. mBio, 12(5), e020622. (Link https://doi.org/10.1128/mBio.02062-21)
Article description: This paper investigates the transcriptional and epigenetic responses of human colonic epithelial (HCE) and human carotid artery endothelial [HCAE] cells to Fusobacterium nucleatum exposure, highlighting its implications in cancer progression and treatment resistance.
- Ana Alonso Bartolomé (https://es.linkedin.com/in/ana-alonso-bartolom%C3%A9-97a3131b7)
Presenter introduction: Ana is a 2nd year PhD student at the Luxembourg Institute of Health. Her research is focused on understanding the role and regulation of ubiquitination in the signaling and trafficking of chemokine receptors.
Article: Ubiquitylation of the chemokine receptor CCR7 enables efficient receptor recycling and cell migration, Schaeuble, et al. 2012 (https://doi.org/10.1242/jcs.097519)
Summary: In this paper, the authors discovered that the chemokine receptor CCR7, essential for lymphocyte and dendritic cell homing to secondary lymphoid organs, is constitutively ubiquitylated. They next developed a ubiquitylation-deficient CCR7 and observed that this mutant internalized normally after ligand binding, but inefficiently recycled and would instead transiently accumulate in the trans-Golgi network compartment. Finally, they showed that immune cells expressing the CCR7 mutant presented an impaired migration in chemotaxis assays, highlighting the importance of ubiquitin in the regulation of CCR7 recycling and immune cell migration.
If we attracted your interest by now, feel free to join the monthly Pizza Club, either as part of Audience or as a registered Speaker. For the latter, please kindly use this form to sign up as an upcoming Speaker, by choosing your category of paper and desired month to present. Looking forward to seeing you at the next Pizza Club!
